Peer Reviewed Work Supporting Our Therapeutic Approach

Allogeneic CAR T

Jacobson C.A. et al (2019, December). Initial Findings of the Phase 1 Trial of PBCAR0191, a CD19 Targeted Allogeneic CAR-T Cell Therapy. Poster session at the American Society of Hematology Annual Meeting, Orlando, FL.

McCreedy, B. J. et al. Off the shelf T cell therapies for hematologic malignancies. Best Pract Res Clin Haematol. 2, 166-175 (2018).

Macleod, D.T. et al.  Integration of a CD19 CAR into the TCR alpha chain locus streamlines production of allogeneic gene-edited CAR T cells. Mol Ther. 4, 949-961 (2017)PDF


In vivo gene correction

Wang, L. et al.  Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol. Nat Biotechnol. 8, 717-725 (2018).

-Press release from Penn Medicine

-Write up in Science